Vimentin

VIM
Identifiers
Aliases	VIM, CTRCT30, HEL113, vimentin
External IDs	OMIM: 193060; MGI: 98932; GeneCards: VIM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GK4, 1GK6, 1GK7, 3G1E, 3KLT, 3S4R, 3SSU, 3SWK, 3TRT, 3UF1, 4MCY, 4MCZ, 4MD0, 4MD5, 4MDJ, 4YPC, 4YV3
Gene location (Human) Chr. Chromosome 10 (human) Band 10p13 Start 17,228,241 bp End 17,237,593 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 A1|2 10.04 cM Start 13,578,738 bp End 13,587,637 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone Descending thoracic aorta right coronary artery synovial membrane spinal ganglia popliteal artery tibial arteries decidua ascending aorta tibial nerve Top expressed in endothelial cell of lymphatic vessel left lung lobe dermis Gonadal ridge external carotid artery tunica media of zone of aorta stroma of bone marrow internal carotid artery ascending aorta semi-lunar valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function scaffold protein binding structural molecule activity structural constituent of cytoskeleton protein C-terminus binding protein binding structural constituent of eye lens identical protein binding double-stranded RNA binding keratin filament binding protein domain specific binding Cellular component cytoplasm cytosol cell projection focal adhesion plasma membrane peroxisome cell leading edge neuron projection extracellular exosome cytoskeleton intermediate filament extracellular matrix nucleus polysome nuclear matrix phagocytic vesicle ribonucleoprotein complex Biological process intermediate filament organization negative regulation of neuron projection development SMAD protein signal transduction astrocyte development intermediate filament-based process positive regulation of gene expression muscle filament sliding Bergmann glial cell differentiation viral process lens fiber cell development cytokine-mediated signaling pathway positive regulation of collagen biosynthetic process regulation of mRNA stability positive regulation of translation cellular response to lipopolysaccharide cellular response to muramyl dipeptide cellular response to interferon-gamma Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 7431 22352 Ensembl ENSG00000026025 ENSMUSG00000026728 UniProt P08670 P20152 RefSeq (mRNA) NM_003380 NM_011701 RefSeq (protein) NP_003371 NP_035831 Location (UCSC) Chr 10: 17.23 – 17.24 Mb Chr 2: 13.58 – 13.59 Mb PubMed search
Wikidata
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Immunofluorescence staining pattern of vimentin antibodies. Produced by incubating vimentin primary antibodies and FITC labelled secondary antibodies with HEp-20-10 cells.

Vimentin is a structural protein that in humans is encoded by the VIM gene. Its name comes from the Latin vimentum, meaning an osier, withy (array of flexible rods).

Immunofluorescence staining of HeLa Cells with antibody to reveal vimentin containing intermediate filaments in green and antibody to LAMP1 to reveal lysosomes in red. Nuclear DNA is seen in blue. Antibodies and image courtesy EnCor Biotechnology Inc.

Vimentin is a type III intermediate filament (IF) protein that is expressed in mesenchymal cells. IF proteins are found in all animal cells as well as bacteria. Intermediate filaments, along with tubulin-based microtubules and actin-based microfilaments, comprise the cytoskeleton. All IF proteins are expressed in a highly developmentally-regulated fashion; vimentin is the major cytoskeletal component of mesenchymal cells. Because of this, vimentin is often used as a marker of mesenchymally-derived cells or cells undergoing an epithelial-to-mesenchymal transition (EMT) during both normal development and metastatic progression.