Trypsin-2

PRSS2
Identifiers
Aliases	PRSS2, TRY2, TRY8, TRYP2, protease, serine 2, serine protease 2
External IDs	OMIM: 601564; MGI: 102759; GeneCards: PRSS2
Enzyme activity
Gene location (Human)
Chr.	Chromosome 7 (human)
End	142,774,564 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	41,502,013 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; islet of Langerhans; ; duodenum; ; testicle; ; fundus; ; ectocervix; ; right coronary artery; ; body of stomach; ; canal of the cervix; ; right uterine tube;
	Top expressed in
	pyloric antrum; ; islet of Langerhans; ; pancreatic acinus; ; duodenum; ; sexually immature organism; ; mucous cell of stomach; ; masseter muscle; ; intercostal muscle; ; brown adipose tissue; ; quadriceps femoris muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; peptidase activity; protein binding; hydrolase activity; metal ion binding; serine-type endopeptidase activity; serine-type peptidase activity; metalloendopeptidase activity;
Cellular component	extracellular matrix; extracellular region; extracellular space; azurophil granule lumen;
Biological process	collagen catabolic process; digestion; positive regulation of cell growth; extracellular matrix disassembly; proteolysis; positive regulation of cell adhesion; antimicrobial humoral response; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5645
	22072
	ENSG00000282049; ENSG00000275896
	ENSMUSG00000057163
	P07478
	P07146
	NM_001303414; NM_002770
	NM_009430
	NP_001290343; NP_002761
	NP_033456
	Wikidata
View/Edit Human	View/Edit Mouse

Trypsin-2 (also called serine protease 2) is an enzyme that in humans is encoded by the PRSS2 gene. Trypsin-2 is a digestive enzyme which functions to break down proteins as a protease. Like other trypsins it is secreted in its inactive, trypsinogen form by the acinar cells of the pancreas into the small intestines as part of pancreatic juice. It is distinctive in its potential ability to degrade type II collagen, which may be connected to rheumatoid arthritis.