Tropomyosin receptor kinase B

NTRK2
Identifiers
Aliases	NTRK2, GP145-TrkB, TRKB, trk-B, neurotrophic receptor tyrosine kinase 2, OBHD, EIEE58
External IDs	OMIM: 600456; MGI: 97384; GeneCards: NTRK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AT5, 1HCF, 1WWB, 2MFQ, 4ASZ, 4AT3, 4AT4
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.7.10.1 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 9 (human) Band 9q21.33 Start 84,668,551 bp End 85,027,070 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 B1|13 31.2 cM Start 58,954,383 bp End 59,281,784 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in optic nerve external globus pallidus Region I of hippocampus proper internal globus pallidus Epithelium of choroid plexus superior vestibular nucleus dorsal motor nucleus of vagus nerve ventral tegmental area postcentral gyrus pars reticulata Top expressed in median eminence arcuate nucleus dorsomedial hypothalamic nucleus lateral septal nucleus superior frontal gyrus substantia nigra subiculum anterior amygdaloid area dorsal tegmental nucleus Epithelium of choroid plexus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neurotrophin binding neurotrophin receptor activity kinase activity transmembrane receptor protein tyrosine kinase activity ATP binding protein kinase activity brain-derived neurotrophic factor binding transferase activity protein homodimerization activity protein tyrosine kinase activity nucleotide binding brain-derived neurotrophic factor-activated receptor activity protein binding receptor tyrosine kinase transmembrane signaling receptor activity Cellular component cytosol endosome postsynaptic membrane membrane terminal bouton integral component of membrane receptor complex endosome membrane integral component of plasma membrane postsynaptic density early endosome early endosome membrane plasma membrane axon dendrite perinuclear region of cytoplasm cytoplasm cell projection dendritic spine axon terminus Golgi membrane Biological process negative regulation of neuron apoptotic process peripheral nervous system neuron development positive regulation of protein phosphorylation oligodendrocyte differentiation learning positive regulation of axonogenesis vasculogenesis protein phosphorylation central nervous system neuron development neuromuscular junction development retinal rod cell development circadian rhythm feeding behavior regulation of GTPase activity positive regulation of peptidyl-serine phosphorylation brain-derived neurotrophic factor receptor signaling pathway regulation of protein kinase B signaling regulation of metabolic process positive regulation of MAPK cascade cell differentiation phosphorylation neuron migration mechanoreceptor differentiation nervous system development glutamate secretion retina development in camera-type eye neuron differentiation cerebral cortex development negative regulation of anoikis multicellular organism development positive regulation of gene expression positive regulation of cell population proliferation positive regulation of neuron projection development cellular response to amino acid stimulus positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation long-term potentiation positive regulation of synapse assembly transmembrane receptor protein tyrosine kinase signaling pathway protein autophosphorylation trans-synaptic signaling by neuropeptide, modulating synaptic transmission activation of phospholipase C activity neurotrophin TRK receptor signaling pathway positive regulation of non-membrane spanning protein tyrosine kinase activity trans-synaptic signaling by BDNF, modulating synaptic transmission negative regulation of signal transduction neuronal action potential propagation myelination in peripheral nervous system negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade cellular response to nerve growth factor stimulus regulation of MAPK cascade cellular response to brain-derived neurotrophic factor stimulus Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 4915 18212 Ensembl ENSG00000148053 ENSMUSG00000055254 UniProt Q16620 P15209 RefSeq (mRNA) NM_001007097 NM_001018064 NM_001018065 NM_001018066 NM_001291937 NM_006180 NM_001025074 NM_008745 NM_001282961 RefSeq (protein) NP_001007098 NP_001018074 NP_001018075 NP_001018076 NP_001278866 NP_006171 NP_001356461 NP_001356462 NP_001356463 NP_001356464 NP_001356465 NP_001356466 NP_001356467 NP_001356468 NP_001356469 NP_001356470 NP_001356471 NP_001356472 NP_001356473 NP_001356474 NP_001356475 NP_001356476 NP_001356477 NP_001356478 NP_001356479 NP_001356480 NP_001356481 NP_001020245 NP_001269890 NP_032771 Location (UCSC) Chr 9: 84.67 – 85.03 Mb Chr 13: 58.95 – 59.28 Mb PubMed search
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Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene. TrkB is a receptor for brain-derived neurotrophic factor (BDNF).