Triple-stranded DNA

Triplex DNA structure. The wedges are going from the 5' end to the 3' end. The orange and green chains are in a typical Watson-crick double helix (5'-3'/3'-5', anti/anti). The purple chain additionally pairs with the green chain with Hoogsteen pairing (5'-3'/5'-3', anti/syn). (PDB: 1BWG​)

Triple-stranded DNA (also known as H-DNA or Triplex-DNA) is a DNA structure in which three oligonucleotides wind around each other and form a triple helix. In triple-stranded DNA, the third strand binds to a B-form DNA (via Watson–Crick base-pairing) double helix by forming Hoogsteen base pairs or reversed Hoogsteen hydrogen bonds.

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