Cross-city route

Melbourne tram route 96 is a cross-city route connecting two very different suburbs, East Brunswick and St Kilda.
Ashland/63rd CTA station is a terminus of the Green Line, the only through route to run around the Loop on the Chicago 'L' rapid transit system.

A cross-city route is a public transport route linking one (usually relatively distant) suburb or satellite town of a city or metropolitan area with another suburb/satellite on the opposite side of the city, by running directly through the city center or central business district. Such a route can be operated by various forms of public transport, including commuter rail, rapid transit, trams (streetcars), trolleybuses or motor buses.