Tunable resistive pulse sensing

"TRPS" redirects here. For the Talyllyn Railway Preservation Society, see Talyllyn Railway. For Tricho–rhino–phalangeal syndrome, see Langer–Giedion syndrome.

Tunable resistive pulse sensing (TRPS) is a single-particle technique used to measure the size, concentration and zeta potential of particles as they pass through a size-tunable nanopore.

The technique adapts the principle of resistive pulse sensing, which monitors current flow through an aperture, combined with the use of tunable nanopore technology, allowing the passage of ionic current and particles to be regulated by adjusting the pore size. The addition of the tunable nanopore allows for the measurement of a wider range of particle sizes and improves accuracy.

Tunable resistive pulse sensing (TRPS). Particles crossing a pore are detected as a transient change in the ionic current flow, which is denoted as a blockade event with its amplitude denoted as the blockade magnitude.