TRAF6

TRAF6
Identifiers
Aliases	TRAF6, MGC:3310, RNF85, TNF receptor associated factor 6
External IDs	OMIM: 602355; MGI: 108072; GeneCards: TRAF6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LB4, 1LB5, 1LB6, 2ECI, 2JMD, 3HCS, 3HCT, 3HCU, 4Z8M
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.3.2.27 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 11 (human) Band 11p12 Start 36,483,769 bp End 36,510,272 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E2 Start 101,508,774 bp End 101,532,014 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte endothelial cell gonad islet of Langerhans Achilles tendon middle temporal gyrus testicle ascending aorta monocyte popliteal artery Top expressed in Ileal epithelium genital tubercle tail of embryo lumbar subsegment of spinal cord lumbar spinal ganglion granulocyte thymus ventricular zone condyle fossa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein N-terminus binding histone deacetylase binding ubiquitin protein ligase activity metal ion binding mitogen-activated protein kinase kinase kinase binding zinc ion binding protein binding thioesterase binding ubiquitin conjugating enzyme binding protein kinase binding protein kinase B binding ubiquitin-protein transferase activity identical protein binding ubiquitin protein ligase binding transferase activity tumor necrosis factor receptor binding Cellular component cytoplasm cytosol lipid droplet perinuclear region of cytoplasm cytoplasmic side of plasma membrane nucleus plasma membrane cell cortex endosome membrane CD40 receptor complex protein-containing complex Biological process positive regulation of transcription regulatory region DNA binding response to interleukin-1 toll-like receptor signaling pathway Fc-epsilon receptor signaling pathway odontogenesis of dentin-containing tooth animal organ morphogenesis T-helper 1 type immune response toll-like receptor 9 signaling pathway regulation of apoptotic process ossification cytokine-mediated signaling pathway osteoclast differentiation positive regulation of osteoclast differentiation stimulatory C-type lectin receptor signaling pathway activation of NF-kappaB-inducing kinase activity bone resorption JNK cascade membrane protein intracellular domain proteolysis protein ubiquitination positive regulation of T cell proliferation I-kappaB kinase/NF-kappaB signaling protein autoubiquitination immune system process positive regulation of JUN kinase activity positive regulation of DNA-binding transcription factor activity protein polyubiquitination negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II positive regulation of lipopolysaccharide-mediated signaling pathway positive regulation of NF-kappaB transcription factor activity positive regulation of interleukin-2 production positive regulation of T cell cytokine production immune response negative regulation of transcription, DNA-templated nucleotide-binding oligomerization domain containing signaling pathway positive regulation of protein ubiquitination positive regulation of smooth muscle cell proliferation antigen processing and presentation of exogenous peptide antigen via MHC class II cell development protein K63-linked ubiquitination myeloid dendritic cell differentiation MyD88-dependent toll-like receptor signaling pathway neural tube closure bone remodeling positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling cellular response to lipopolysaccharide T cell receptor signaling pathway activation of protein kinase activity positive regulation of transcription by RNA polymerase II signal transduction cellular response to DNA damage stimulus protein deubiquitination regulation of I-kappaB kinase/NF-kappaB signaling interleukin-1-mediated signaling pathway cellular response to cytokine stimulus positive regulation of NIK/NF-kappaB signaling positive regulation of leukocyte adhesion to vascular endothelial cell Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 7189 22034 Ensembl ENSG00000175104 ENSMUSG00000027164 UniProt Q9Y4K3 P70196 RefSeq (mRNA) NM_145803 NM_004620 NM_009424 NM_001303273 RefSeq (protein) NP_004611 NP_665802 NP_001290202 NP_033450 Location (UCSC) Chr 11: 36.48 – 36.51 Mb Chr 2: 101.51 – 101.53 Mb PubMed search
Wikidata
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TRAF6 is a TRAF human protein.