TRAF3

TRAF3
Identifiers
Aliases	TRAF3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1, TNF receptor associated factor 3, RNF118
External IDs	OMIM: 601896; MGI: 108041; GeneCards: TRAF3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FLK, 1FLL, 1KZZ, 1L0A, 1RF3, 1ZMS, 2ECY, 2GKW
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.3.2.27 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 14 (human) Band 14q32.32 Start 102,777,449 bp End 102,911,500 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12 F1|12 60.94 cM Start 111,132,804 bp End 111,233,587 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue monocyte Brodmann area 46 appendix middle temporal gyrus granulocyte postcentral gyrus lymph node testicle tibia Top expressed in CA3 field vestibular sensory epithelium ventral tegmental area Epithelium of choroid plexus central gray substance of midbrain entorhinal cortex subiculum dorsomedial hypothalamic nucleus lacrimal gland superior colliculus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding signal transducer activity metal ion binding protein binding thioesterase binding protein phosphatase binding protein kinase binding ubiquitin protein ligase binding transferase activity ubiquitin-protein transferase activity tumor necrosis factor receptor binding Cellular component cytoplasm cytosol endosome mitochondrion cytoplasmic side of plasma membrane CD40 receptor complex protein-containing complex Biological process regulation of apoptotic process Toll signaling pathway immune system process TRIF-dependent toll-like receptor signaling pathway protein ubiquitination negative regulation of NF-kappaB transcription factor activity regulation of proteolysis apoptotic process toll-like receptor signaling pathway regulation of cytokine production signal transduction regulation of interferon-beta production innate immune response tumor necrosis factor-mediated signaling pathway regulation of defense response to virus protein deubiquitination Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 7187 22031 Ensembl ENSG00000131323 ENSMUSG00000021277 UniProt Q13114 Q60803 RefSeq (mRNA) NM_001199427 NM_003300 NM_145725 NM_145726 NM_001385142 NM_001385143 NM_001048206 NM_001286122 NM_011632 NM_001364364 RefSeq (protein) NP_001186356 NP_003291 NP_663777 NP_663778 NP_001273051 NP_035762 NP_001351293 Location (UCSC) Chr 14: 102.78 – 102.91 Mb Chr 12: 111.13 – 111.23 Mb PubMed search
Wikidata
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TNF receptor-associated factor (TRAF3) is a protein that in humans is encoded by the TRAF3 gene.