TRAF2

TRAF2
Identifiers
Aliases	TRAF2, MGC:45012, TRAP, TRAP3, TNF receptor associated factor 2, RNF117
External IDs	OMIM: 601895; MGI: 101835; GeneCards: TRAF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3M0D, 1CA4, 1CA9, 1CZY, 1CZZ, 1D00, 1D01, 1D0A, 1D0J, 1F3V, 1QSC, 3KNV, 3M06, 3M0A
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.3.2.27 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 9 (human) Band 9q34.3 Start 136,881,912 bp End 136,926,607 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A3 Start 25,407,994 bp End 25,436,952 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon lymph node right testis cerebellar hemisphere right hemisphere of cerebellum granulocyte left testis ganglionic eminence gonad spleen Top expressed in thymus granulocyte mesenteric lymph nodes lactiferous gland spermatocyte crypt of lieberkuhn of small intestine intestinal villus spleen right kidney ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sphingolipid binding lipid binding CD40 receptor binding mitogen-activated protein kinase kinase kinase binding zinc ion binding signal transducer activity metal ion binding ubiquitin-protein transferase activity protein binding identical protein binding thioesterase binding enzyme binding protein phosphatase binding protein kinase binding ubiquitin protein ligase binding transferase activity tumor necrosis factor receptor binding protein-containing complex binding Cellular component TRAF2-GSTP1 complex AIP1-IRE1 complex ubiquitin ligase complex vesicle membrane cell cortex membrane raft CD40 receptor complex cytoplasmic side of plasma membrane IRE1-TRAF2-ASK1 complex nucleoplasm cytoplasm cytosol protein-containing complex Biological process regulation of apoptotic process positive regulation of tumor necrosis factor-mediated signaling pathway positive regulation of JUN kinase activity negative regulation of glial cell apoptotic process regulation of tumor necrosis factor-mediated signaling pathway protein K63-linked ubiquitination positive regulation of DNA-binding transcription factor activity tumor necrosis factor-mediated signaling pathway activation of NF-kappaB-inducing kinase activity positive regulation of protein homodimerization activity response to endoplasmic reticulum stress protein homotrimerization intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of I-kappaB phosphorylation regulation of JNK cascade protein catabolic process positive regulation of NF-kappaB transcription factor activity positive regulation of interleukin-2 production death-inducing signaling complex assembly positive regulation of T cell cytokine production protein ubiquitination positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of extrinsic apoptotic signaling pathway cellular response to nitric oxide regulation of extrinsic apoptotic signaling pathway via death domain receptors I-kappaB kinase/NF-kappaB signaling activation of cysteine-type endopeptidase activity involved in apoptotic process signal transduction protein autoubiquitination negative regulation of neuron death programmed necrotic cell death apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors protein deubiquitination protein heterooligomerization protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 7186 22030 Ensembl ENSG00000127191 ENSMUSG00000026942 UniProt Q12933 P39429 RefSeq (mRNA) NM_021138 NM_009422 NM_001290413 RefSeq (protein) NP_066961 NP_001277342 NP_033448 Location (UCSC) Chr 9: 136.88 – 136.93 Mb Chr 2: 25.41 – 25.44 Mb PubMed search
Wikidata
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TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene.