Swiss-model
| Swiss-model | |
|---|---|
| Type | Structural bioinformatics tool |
| License | freeware, source code unavailable |
| Website | swissmodel |
Swiss-model (stylized as SWISS-MODEL) is a structural bioinformatics web-server dedicated to homology modeling of 3D protein structures. Before AlphaFold, homology modeling was the most accurate method to generate reliable three-dimensional protein structure models. To this day, it is still used in many practical applications where deep learning techniques fall short because of their data-driven approach. Homology (or comparative) modelling methods make use of experimental protein structures (templates) to build models for evolutionary related proteins (targets).
Today, Swiss-model consists of three tightly integrated components: (1) The Swiss-model pipeline – a suite of software tools and databases for automated protein structure modelling, (2) The Swiss-model Workspace – a web-based graphical user interface workbench, (3) The Swiss-model Repository – a continuously updated database of homology models for a set of model organism proteomes of high biomedical interest.