Sulindac

Sulindac
Clinical data
Trade names	Clinoril
AHFS/Drugs.com	Monograph
MedlinePlus	a681037
Pregnancy; category	AU: C;
Routes of; administration	By mouth
ATC code	M01AB02 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	Approximately 90% (Oral)
Metabolism	?
Elimination half-life	7.8 hours, metabolites up to 16.4 hours
Excretion	Renal (50%) and fecal (25%)
Identifiers
	IUPAC name {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-indene-3-yl}acetic acid;
CAS Number	38194-50-2 ;
PubChem CID	1548887;
IUPHAR/BPS	5425;
DrugBank	DB00605 ;
ChemSpider	1265915 ;
UNII	184SNS8VUH;
KEGG	D00120 ;
ChEBI	CHEBI:9352 ;
ChEMBL	ChEMBL15770 ;
PDB ligand	SUZ (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID4023624 ;
ECHA InfoCard	100.048.909
Chemical and physical data
Formula	C20H17FO3S
Molar mass	356.41 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	182 to 185 °C (360 to 365 °F) (decomp.)
	SMILES CC1=C(CC(O)=O)C2=CC=CC=C2/C1=C\C3=CC=C(S(C)=O)C=C3;
	InChI InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9- ; Key:MLKXDPUZXIRXEP-MFOYZWKCSA-N ;
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Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed as Clinoril. Imbaral is another name for this drug. Its name is derived from sul(finyl)+ ind(ene)+ ac(etic acid) It was patented in 1969 and approved for medical use in 1976.