RPTOR

RPTOR
Identifiers
Aliases	RPTOR, KOG1, Mip1, regulatory associated protein of MTOR complex 1
External IDs	OMIM: 607130; MGI: 1921620; GeneCards: RPTOR
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.3 Start 80,544,819 bp End 80,966,371 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E2 Start 119,493,731 bp End 119,790,402 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve superficial temporal artery gastrocnemius muscle stromal cell of endometrium popliteal artery tibial arteries muscle of thigh muscle layer of sigmoid colon bone marrow cell apex of heart Top expressed in tail of embryo lumbar subsegment of spinal cord gastrula genital tubercle muscle of thigh dentate gyrus of hippocampal formation granule cell otic vesicle spermatid primary visual cortex Rostral migratory stream More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 14-3-3 protein binding protein-containing complex binding TFIIIC-class transcription factor complex binding protein binding protein kinase binding protein-macromolecule adaptor activity protein kinase activator activity protein serine/threonine kinase inhibitor activity Cellular component lysosomal membrane cytoplasm TORC1 complex soma dendrite nucleoplasm cytosol cytoplasmic stress granule lysosome Biological process positive regulation of protein serine/threonine kinase activity positive regulation of endothelial cell proliferation regulation of phosphorylation positive regulation of TOR signaling cellular response to nutrient levels TOR signaling cellular response to amino acid stimulus regulation of cell size positive regulation of transcription by RNA polymerase III regulation of cellular response to heat activation of protein kinase activity cellular response to starvation regulation of autophagy positive regulation of peptidyl-threonine phosphorylation positive regulation of cell growth positive regulation of peptidyl-serine phosphorylation TORC1 signaling negative regulation of protein serine/threonine kinase activity positive regulation of G1/S transition of mitotic cell cycle regulation of macroautophagy cellular response to leucine regulation of cell growth viral process Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 57521 74370 Ensembl ENSG00000141564 ENSMUSG00000025583 UniProt Q8N122 Q8K4Q0 RefSeq (mRNA) NM_020761 NM_001163034 NM_028898 NM_001306081 RefSeq (protein) NP_001156506 NP_065812 n/a Location (UCSC) Chr 17: 80.54 – 80.97 Mb Chr 11: 119.49 – 119.79 Mb PubMed search
Wikidata
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Regulatory-associated protein of mTOR also known as raptor or KIAA1303 is an adapter protein that is encoded in humans by the RPTOR gene. The RPTOR protein is a component of the protein complex mTORC1, a nutrient sensor that promotes cell growth and anabolic reactions in response to nutrients or growth factors. Inside of mTORC1, RPTOR has two major known adaptor functions. In particular, it interacts with Rag GTPases (RRAGA, RRAGB, RRAGC and/or RRAGD), recruiting the complex to lysosome membranes, and also binds to TOS motif-containing proteins, and directs them to the complex’s phosphorylating domain. Two mRNAs from the gene have been identified that encode proteins of 1335 (isoform 1) and 1177 (isoform 2) amino acids long.