Replication protein A3

RPA3
Identifiers
Aliases	RPA3, REPA3, RP-A p14, replication protein A3
External IDs	OMIM: 179837; MGI: 1915490; GeneCards: RPA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1L1O, 1QUQ, 2PI2, 2PQA, 2Z6K, 3KDF
Gene location (Human) Chr. Chromosome 7 (human) Band 7p21.3 Start 7,636,518 bp End 7,718,607 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 A1 Start 8,255,936 bp End 8,259,173 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell beta cell trabecular bone embryo ventricular zone bone marrow olfactory zone of nasal mucosa nasal epithelium ganglionic eminence mucosa of transverse colon Top expressed in medial ganglionic eminence otic placode zygote yolk sac thymus dermis mandibular prominence maxillary prominence embryo ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function single-stranded DNA binding DNA binding damaged DNA binding protein binding Cellular component nucleus nucleoplasm DNA replication factor A complex site of double-strand break Biological process DNA recombination translesion synthesis DNA replication nucleotide-excision repair, DNA gap filling transcription-coupled nucleotide-excision repair regulation of cell population proliferation nucleotide-excision repair, DNA incision error-free translesion synthesis cellular response to DNA damage stimulus regulation of mitotic cell cycle regulation of cellular response to heat interstrand cross-link repair error-prone translesion synthesis nucleotide-excision repair, DNA incision, 5'-to lesion nucleotide-excision repair, preincision complex stabilization nucleotide-excision repair DNA repair base-excision repair double-strand break repair via homologous recombination nucleotide-excision repair, preincision complex assembly telomere maintenance telomere maintenance via semi-conservative replication G1/S transition of mitotic cell cycle DNA mismatch repair nucleotide-excision repair, DNA incision, 3'-to lesion regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 6119 68240 Ensembl ENSG00000106399 ENSMUSG00000012483 UniProt P35244 Q9CQ71 RefSeq (mRNA) NM_002947 NM_026632 RefSeq (protein) NP_002938 NP_080908 Location (UCSC) Chr 7: 7.64 – 7.72 Mb Chr 6: 8.26 – 8.26 Mb PubMed search
Wikidata
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Replication protein A 14 kDa subunit is a protein that in humans is encoded by the RPA3 gene. RPA is a single-stranded DNA-binding protein that is conserved in eukaryotes and plays essential roles in the metabolism of nucleic acids. Unlike helicase, RPA does not separate strands but binds and protects exposed single-stranded DNA to prevent secondary structure formation and degradation. RPA is usually considered to be the functional equivalent of bacterial single-stranded DNA-binding proteins (SSB), although it is much more complex structurally in eukaryotic cells.