Pyruvate kinase

Pyruvate kinase
3D structure of pyruvate kinase (1PKN)
Identifiers
EC no.2.7.1.40
CAS no.9001-59-6
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Pyruvate kinase is the enzyme involved in the last step of glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvic acid (PEP) to adenosine diphosphate (ADP), yielding one molecule of pyruvic acid and one molecule of adenosine triphosphate (ATP).

ADP +
 
2D representation of the chemical structure of phosphoenolpyruvic acid.
PEP
 
 
 
Rightward reaction arrow
 
 
 
ATP +
 
2D representation of the chemical structure of pyruvic acid.
pyruvic acid

Pyruvate kinase was inappropriately named (inconsistently with a conventional kinase) before it was recognized that it did not directly catalyze phosphorylation of pyruvic acid, which does not occur under physiological conditions. Pyruvate kinase is present in four distinct, tissue-specific isozymes in animals, each consisting of particular kinetic properties necessary to accommodate the variations in metabolic requirements of diverse tissues.

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