PLOS

Public Library of Science
	PLOS logo since March 2020
Status	Active
Founded	2000; October 13, 2003 (public operations);
Founder	Harold E. Varmus; Michael Eisen; Patrick O. Brown;
Country of origin	United States
Headquarters location	Levi's Plaza, San Francisco, California
Key people	Alison Mudditt (CEO)
Publication types	Academic journals
Nonfiction topics	Science
Official website	plos.org

PLOS (for Public Library of Science; PLoS until 2012) is a nonprofit publisher of open-access journals in science, technology, and medicine and other scientific literature, under an open-content license. It was founded in 2000 and launched its first journal, PLOS Biology, in October 13, 2003.

As of 2024, PLOS publishes 14 academic journals, including seven journals indexed within the Science Citation Index Expanded, and consequently seven journals ranked with an impact factor.

PLOS journals are included in the Directory of Open Access Journals (DOAJ). PLOS is also a member of the Open Access Scholarly Publishers Association (OASPA), a participating publisher and supporter of the Initiative for Open Citations, and a member of the Committee on Publication Ethics (COPE).