PRKAA2

PRKAA2
Identifiers
Aliases	PRKAA2, AMPK, AMPK2, AMPKa2, PRKAA, protein kinase AMP-activated catalytic subunit alpha 2
External IDs	OMIM: 600497; MGI: 1336173; GeneCards: PRKAA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2H6D, 2LTU, 2YZA, 3AQV, 4CFE, 4CFF, 4ZHX, 5EZV
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	56,715,335 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	104,967,087 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; right ventricle; ; body of tongue; ; renal medulla; ; saphenous vein; ; muscle of thigh; ; vena cava; ; Brodmann area 23;
	Top expressed in
	triceps brachii muscle; ; medial head of gastrocnemius muscle; ; vastus lateralis muscle; ; sternocleidomastoid muscle; ; tibialis anterior muscle; ; knee joint; ; digastric muscle; ; temporal muscle; ; soleus muscle; ; extraocular muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; [acetyl-CoA carboxylase kinase activity]; AMP-activated protein kinase activity; histone serine kinase activity; chromatin binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; [hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity]; protein serine/threonine/tyrosine kinase activity; ATP binding;
Cellular component	cytoplasm; cytosol; nucleoplasm; nucleotide-activated protein kinase complex; nucleus; Golgi apparatus; nuclear speck; cytoplasmic stress granule; axon; dendrite; soma;
Biological process	carnitine shuttle; steroid metabolic process; intracellular signal transduction; cellular response to glucose starvation; sterol biosynthetic process; lipid biosynthetic process; regulation of transcription, DNA-templated; glucose homeostasis; positive regulation of autophagy; phosphorylation; rhythmic process; lipid metabolism; response to stress; negative regulation of apoptotic process; cholesterol metabolic process; Wnt signaling pathway; regulation of fatty acid biosynthetic process; fatty acid metabolic process; transcription, DNA-templated; cellular response to prostaglandin E stimulus; autophagy; protein phosphorylation; negative regulation of TOR signaling; positive regulation of macroautophagy; fatty acid biosynthetic process; fatty acid homeostasis; regulation of circadian rhythm; cellular response to nutrient levels; regulation of gene expression; cholesterol biosynthetic process; response to muscle activity; positive regulation of glycolytic process; macroautophagy; signal transduction; steroid biosynthetic process; regulation of signal transduction by p53 class mediator; regulation of macroautophagy; chromatin organization; negative regulation of gene expression; cellular response to oxidative stress; regulation of stress granule assembly; regulation of microtubule cytoskeleton organization; cellular response to calcium ion; cellular response to glucose stimulus; energy homeostasis; positive regulation of protein localization; negative regulation of tubulin deacetylation; positive regulation of peptidyl-lysine acetylation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5563
	108079
	ENSG00000162409
	ENSMUSG00000028518
	P54646
	Q8BRK8
	NM_006252
	NM_178143; NM_001356568
	NP_006243
	NP_835279; NP_001343497
	Wikidata
View/Edit Human	View/Edit Mouse

5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene.