PIEZO2

PIEZO2
Identifiers
Aliases	PIEZO2, C18orf30, C18orf58, DA3, DA5, FAM38B, FAM38B2, HsT748, HsT771, MWKS, piezo type mechanosensitive ion channel component 2, DAIPT
External IDs	OMIM: 613629; MGI: 1918781; GeneCards: PIEZO2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	6KG7
Gene location (Human)
Chr.	Chromosome 18 (human)
End	11,149,569 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	63,520,254 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; corpus callosum; ; spinal ganglia; ; visceral pleura; ; inferior ganglion of vagus nerve; ; trigeminal ganglion; ; parietal pleura; ; optic nerve; ; C1 segment; ; Achilles tendon;
	Top expressed in
	lumbar spinal ganglion; ; prostate; ; lobe of prostate; ; cumulus cell; ; trigeminal ganglion; ; genital tubercle; ; hand; ; aortic valve; ; ascending aorta; ; gastrula;
	More reference expression data
	n/a
Gene ontology
Molecular function	cation channel activity; mechanosensitive ion channel activity;
Cellular component	membrane; integral component of membrane; plasma membrane;
Biological process	ion transmembrane transport; response to mechanical stimulus; ion transport; response to stimulus; cation transport; detection of mechanical stimulus involved in sensory perception; regulation of membrane potential; detection of mechanical stimulus; cellular response to mechanical stimulus; cation transmembrane transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	63895
	667742
	ENSG00000154864
	ENSMUSG00000041482
	Q9H5I5
	Q8CD54
	NM_022068; NM_173817; NM_001378183
	NM_001039485; NM_172629
	NP_071351; NP_001365112
	NP_001034574
	Wikidata
View/Edit Human	View/Edit Mouse

Piezo-type mechanosensitive ion channel component 2 is a protein that in humans is encoded by the PIEZO2 gene. The PIEZO2 protein has a role in mechanotransduction. Mechanical activation of the channel leads to depolarization of the plasma membrane or activation of secondary messenger cascades. PIEZO2 was cloned in 2010 after its homolog, PIEZO1, was identified using small interfering RNAs of candidate genes for mechanically activated ion channels in mouse neurons. It has a homotrimeric structure, with three blades curving into a nano-dome, with a diameter of 28 nanometers (nm). 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.'