PER2

PER2
Identifiers
Aliases	PER2, FASPS, FASPS1, period circadian clock 2, period circadian regulator 2
External IDs	OMIM: 603426; MGI: 1195265; GeneCards: PER2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3GDI, 4CT0, 4U8H
Gene location (Human) Chr. Chromosome 2 (human) Band 2q37.3 Start 238,244,044 bp End 238,290,102 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 D Start 91,343,704 bp End 91,387,046 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte mucosa of paranasal sinus secondary oocyte bronchial epithelial cell palpebral conjunctiva nasal epithelium tail of epididymis urethra caput epididymis skin of thigh Top expressed in adrenal gland left lung lobe suprachiasmatic nucleus granulocyte rectum lacrimal gland median eminence primary motor cortex lobe of cerebellum respiratory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity transcription cis-regulatory region binding protein binding transcription corepressor binding transcription factor binding Cellular component nucleolus perinuclear region of cytoplasm nucleus cytoplasm Biological process histone H3 deacetylation gluconeogenesis regulation of transcription, DNA-templated regulation of insulin secretion rhythmic process negative regulation of fat cell proliferation negative regulation of circadian rhythm negative regulation of transcription by RNA polymerase II circadian regulation of gene expression transcription, DNA-templated fatty acid metabolic process regulation of cell cycle negative regulation of protein ubiquitination circadian regulation of translation response to ischemia regulation of vasoconstriction glycogen biosynthetic process negative regulation of transcription regulatory region DNA binding regulation of circadian rhythm circadian rhythm white fat cell differentiation regulation of glutamate uptake involved in transmission of nerve impulse lactate biosynthetic process negative regulation of transcription, DNA-templated regulation of neurogenesis positive regulation of nucleic acid-templated transcription response to light stimulus entrainment of circadian clock by photoperiod positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 8864 18627 Ensembl ENSG00000132326 ENSMUSG00000055866 UniProt O15055 O54943 RefSeq (mRNA) NM_003894 NM_022817 NM_011066 RefSeq (protein) NP_073728 NP_035196 Location (UCSC) Chr 2: 238.24 – 238.29 Mb Chr 1: 91.34 – 91.39 Mb PubMed search
Wikidata
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PER2 is a protein in mammals encoded by the PER2 gene. PER2 is noted for its major role in circadian rhythms.