Pyruvate dehydrogenase phosphatase

PDP1
Identifiers
Aliases	PDP1, PDH, PDP, PDPC, PPM2C, PPM2A, pyruvate dehyrogenase phosphatase catalytic subunit 1, pyruvate dehydrogenase phosphatase catalytic subunit 1
External IDs	OMIM: 605993; MGI: 2685870; GeneCards: PDP1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 8 (human)
End	93,926,068 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	11,966,452 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; buccal mucosa cell; ; biceps brachii; ; parietal lobe; ; postcentral gyrus; ; Brodmann area 23; ; right ventricle; ; superior frontal gyrus; ; Skeletal muscle tissue of biceps brachii; ; primary visual cortex;
	Top expressed in
	lateral geniculate nucleus; ; medial dorsal nucleus; ; medial geniculate nucleus; ; olfactory tubercle; ; primary motor cortex; ; prefrontal cortex; ; piriform cortex; ; seminal vesicula; ; cingulate gyrus; ; lateral septal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein serine/threonine phosphatase activity; protein binding; catalytic activity; phosphoprotein phosphatase activity; hydrolase activity; cation binding; metal ion binding; [pyruvate dehydrogenase (lipoamide) phosphatase activity];
Cellular component	mitochondrial matrix; mitochondrion;
Biological process	protein dephosphorylation; regulation of acetyl-CoA biosynthetic process from pyruvate; peptidyl-threonine dephosphorylation; positive regulation of pyruvate dehydrogenase activity;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	54704
	381511
	ENSG00000164951
	ENSMUSG00000049225
	Q9P0J1
	Q3UV70
	NM_001161778; NM_001161779; NM_001161780; NM_001161781; NM_018444
	NM_001033453; NM_001098230; NM_001098231; NM_001290387; NM_001290391
	NP_001155251; NP_001155252; NP_001155253; NP_060914
	NP_001028625; NP_001091700; NP_001091701; NP_001277316; NP_001277320
	Wikidata
View/Edit Human	View/Edit Mouse

Pyruvate dehydrogenase phosphatase catalytic subunit 1 (PDPC 1), also known as protein phosphatase 2C, is an enzyme that in humans is encoded by the PDP1 gene. PDPC 1 is an enzyme which serves to reverse the effects of pyruvate dehydrogenase kinase upon pyruvate dehydrogenase, activating pyruvate dehydrogenase.