P protein

OCA2
Identifiers
Aliases	OCA2, BEY, BEY1, BEY2, BOCA, D15S12, EYCL, EYCL2, EYCL3, HCL3, PED, SHEP1, OCA2 melanosomal transmembrane protein, P
External IDs	OMIM: 611409; MGI: 97454; GeneCards: OCA2
Gene location (Human)
Chr.	Chromosome 15 (human)
End	28,099,315 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	56,186,266 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; Epithelium of choroid plexus; ; secondary oocyte; ; hair follicle; ; testicle; ; male germ cell; ; epithelium of nasopharynx; ; sperm; ; skin of arm; ; vulva;
	Top expressed in
	iris; ; retinal pigment epithelium; ; choroid plexus of fourth ventricle; ; ciliary body; ; Epithelium of choroid plexus; ; hair follicle; ; epithelium of lens; ; primary oocyte; ; barrel cortex; ; corneal stroma;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity; L-tyrosine transmembrane transporter activity; protein binding;
Cellular component	endoplasmic reticulum membrane; lysosomal membrane; endosome membrane; membrane; cytoplasm; melanosome membrane; integral component of membrane;
Biological process	eye pigment biosynthetic process; pigmentation; developmental pigmentation; melanin biosynthetic process; cell population proliferation; transmembrane transport; spermatid development; melanocyte differentiation; tyrosine transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	4948
	18431
	ENSG00000104044; ENSG00000277361
	ENSMUSG00000030450
	Q04671
	Q62052
	NM_000275; NM_001300984
	NM_021879
	NP_000266; NP_001287913
	NP_068679
	Wikidata
View/Edit Human	View/Edit Mouse

P protein, also known as melanocyte-specific transporter protein or pink-eyed dilution protein homolog, is a protein that in humans is encoded by the oculocutaneous albinism II (OCA2) gene. The P protein is believed to be an integral membrane protein involved in small molecule transport, specifically of tyrosine—a precursor of melanin. Certain mutations in OCA2 result in type 2 oculocutaneous albinism. OCA2 encodes the human homologue of the mouse p (pink-eyed dilution) gene.

In human, the OCA2 gene is located on the long (q) arm of chromosome 15 between positions 12 and 13.1

The human OCA2 gene is located on the long arm (q) of chromosome 15, specifically from base pair 28,000,020 to base pair 28,344,457 on chromosome 15.