Notch 1

NOTCH1
Identifiers
Aliases	NOTCH1, Notch1, 9930111A19Rik, Mis6, N1, Tan1, lin-12, AOS5, AOVD1, hN1, notch 1, notch receptor 1
External IDs	OMIM: 190198; MGI: 97363; GeneCards: NOTCH1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PB5, 1TOZ, 1YYH, 2F8X, 2F8Y, 2HE0, 2VJ3, 3ETO, 3I08, 3L95, 3NBN, 3V79, 4CUD, 4CUE, 4CUF, 4D0E, 4D0F, 5FM9, 5FMA
Gene location (Human) Chr. Chromosome 9 (human) Band 9q34.3 Start 136,494,433 bp End 136,546,048 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 A3|2 18.91 cM Start 26,347,915 bp End 26,406,675 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone epithelium of colon visceral pleura external globus pallidus ganglionic eminence blood gingival epithelium superficial temporal artery granulocyte vulva Top expressed in hair follicle vestibular sensory epithelium vasculature of trunk Rostral migratory stream granulocyte transitional epithelium of urinary bladder conjunctival fornix renal corpuscle skin of back vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding DNA-binding transcription factor activity Notch binding enzyme inhibitor activity metal ion binding enzyme binding chromatin binding protein binding sequence-specific DNA binding protein heterodimerization activity chromatin DNA binding transmembrane signaling receptor activity signaling receptor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component cytoplasm cytosol membrane adherens junction extracellular region nucleus cell surface apical plasma membrane endoplasmic reticulum integral component of membrane Golgi apparatus receptor complex plasma membrane nucleoplasm MAML1-RBP-Jkappa- ICN1 complex cell periphery endoplasmic reticulum membrane Golgi membrane acrosomal vesicle cytoplasmic vesicle Biological process cardiac vascular smooth muscle cell development endoderm development pulmonary valve morphogenesis positive regulation of endothelial cell differentiation regulation of somitogenesis cell differentiation in spinal cord negative regulation of neuron differentiation regulation of extracellular matrix assembly distal tubule development negative regulation of glial cell proliferation epithelial to mesenchymal transition involved in endocardial cushion formation regulation of transcription by RNA polymerase II aortic valve morphogenesis oligodendrocyte differentiation endocardium morphogenesis negative regulation of osteoblast differentiation negative regulation of stem cell differentiation negative regulation of ossification heart looping negative regulation of photoreceptor cell differentiation arterial endothelial cell differentiation atrioventricular valve morphogenesis Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation humoral immune response foregut morphogenesis negative regulation of oligodendrocyte differentiation positive regulation of cardiac muscle cell proliferation regulation of developmental process mesenchymal cell development animal organ regeneration angiogenesis spermatogenesis negative regulation of pro-B cell differentiation regulation of cardioblast proliferation hair follicle morphogenesis vasculogenesis involved in coronary vascular morphogenesis negative regulation of canonical Wnt signaling pathway regulation of neurogenesis negative regulation of cell population proliferation collecting duct development positive regulation of neuroblast proliferation cilium assembly heart trabecula morphogenesis atrioventricular node development negative regulation of myoblast differentiation cell fate commitment regulation of transcription, DNA-templated cellular response to follicle-stimulating hormone stimulus lung development negative regulation of inner ear auditory receptor cell differentiation cardiac septum morphogenesis ventricular septum morphogenesis negative regulation of cell differentiation coronary artery morphogenesis response to muramyl dipeptide cardiac left ventricle morphogenesis in utero embryonic development negative regulation of cell death endocardial cell differentiation transcription, DNA-templated positive regulation of transcription, DNA-templated development of the heart prostate gland epithelium morphogenesis embryonic limb morphogenesis growth involved in heart morphogenesis neural tube development pericardium morphogenesis epidermis development cardiac atrium morphogenesis transcription initiation from RNA polymerase II promoter cardiac right atrium morphogenesis negative regulation of cell-substrate adhesion cell migration involved in endocardial cushion formation cell differentiation venous endothelial cell differentiation regulation of inner ear auditory receptor cell differentiation negative regulation of catalytic activity inflammatory response to antigenic stimulus positive regulation of astrocyte differentiation positive regulation of epithelial cell proliferation cardiac right ventricle formation endocardial cushion development cell fate specification positive regulation of keratinocyte differentiation positive regulation of glial cell differentiation negative regulation of neurogenesis glomerular mesangial cell development sprouting angiogenesis glial cell differentiation negative regulation of transcription by RNA polymerase II cardiac muscle cell proliferation secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development positive regulation of epithelial to mesenchymal transition ventricular trabecula myocardium morphogenesis neuronal stem cell population maintenance negative regulation of cell migration involved in sprouting angiogenesis response to lipopolysaccharide compartment pattern specification immune response neuron differentiation epithelial to mesenchymal transition positive regulation of BMP signaling pathway skeletal muscle cell differentiation regulation of gene expression positive regulation of viral genome replication regulation of epithelial cell proliferation involved in prostate gland development negative regulation of transcription, DNA-templated cardiac ventricle morphogenesis branching morphogenesis of an epithelial tube positive regulation of receptor signaling pathway via JAK-STAT negative regulation of anoikis Notch signaling involved in heart development coronary vein morphogenesis apoptotic process involved in embryonic digit morphogenesis regulation of cell migration axonogenesis tissue regeneration positive regulation of cell migration somatic stem cell division cardiac muscle tissue morphogenesis negative regulation of endothelial cell chemotaxis keratinocyte differentiation negative regulation of BMP signaling pathway endocardial cushion morphogenesis endocardium development multicellular organism development auditory receptor cell fate commitment response to corticosteroid tube formation determination of left/right symmetry astrocyte differentiation negative regulation of calcium ion-dependent exocytosis brain development regulation of cell population proliferation positive regulation of cell population proliferation negative regulation of myotube differentiation positive regulation of apoptotic process positive regulation of transcription from RNA polymerase II promoter in response to hypoxia mitral valve formation liver development cardiac chamber formation forebrain development cellular response to vascular endothelial growth factor stimulus neuron fate commitment regulation of epithelial cell proliferation regulation of Notch signaling pathway left/right axis specification positive regulation of transcription by RNA polymerase II cardiac epithelial to mesenchymal transition embryonic hindlimb morphogenesis positive regulation of aorta morphogenesis venous blood vessel morphogenesis Notch signaling pathway negative regulation of gene expression negative regulation of growth rate positive regulation of Ras protein signal transduction positive regulation of ERK1 and ERK2 cascade positive regulation of transcription of Notch receptor target positive regulation of Notch signaling pathway outflow tract morphogenesis coronary sinus valve morphogenesis negative regulation of cell proliferation involved in heart valve morphogenesis negative regulation of extracellular matrix constituent secretion negative regulation of cardiac muscle hypertrophy positive regulation of gene expression homeostasis of number of cells within a tissue negative regulation of biomineral tissue development positive regulation of apoptotic process involved in morphogenesis positive regulation of cardiac epithelial to mesenchymal transition negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 4851 18128 Ensembl ENSG00000148400 ENSMUSG00000026923 UniProt P46531 Q01705 RefSeq (mRNA) NM_017617 NM_008714 RefSeq (protein) NP_060087 NP_032740 Location (UCSC) Chr 9: 136.49 – 136.55 Mb Chr 2: 26.35 – 26.41 Mb PubMed search
Wikidata
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Neurogenic locus notch homolog protein 1 (Notch 1) is a protein encoded in humans by the NOTCH1 gene. Notch 1 is a single-pass transmembrane receptor.