Major Mackenzie Drive
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| York Regional Road 25 | |||||||
 Major Mackenzie Drive looking west to Jane Street and Canada's Wonderland | |||||||
 Route of Major Mackenzie Drive across York Region (blue line) | |||||||
| Namesake | Addison Alexander MacKenzie | ||||||
| Maintained by | Region of York | ||||||
| Length | 40.4 km (25.1 mi) | ||||||
| Location | York Region (Vaughan, Richmond Hill, Markham) | ||||||
| West end |  (Former) Highway 50 In Brampton (Continues north as Coleraine Drive into Brampton) | ||||||
Major junctions |  Highway 427 (Former) Highway 27 Islington Avenue Weston Road Highway 400 Jane Street Keele Street Dufferin Street Bathurst Street Yonge Street Bayview Avenue Leslie Street Highway 404 Woodbine Avenue Warden Avenue Kennedy Road McCowan Road Highway 48 /  Markham Road Donald Cousens Parkway | ||||||
| East end |   York-Durham Line | ||||||
| Other | |||||||
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Major Mackenzie Drive, often shortened to Major Mac, is a major east-west arterial road in southern York Region, Ontario, Canada, just north of Toronto. It is a York regional road, numbered as York Regional Road 25, and passes through the three cities of southern York Region: Vaughan, Ontario, Richmond Hill, and Markham. It does not continue outside of York Region as an east-west road, but does cross into Brampton (in Peel Region) as Coleraine Drive which immediately curves sharply at the boundary to head north towards Bolton.