MS4A2

MS4A2
Identifiers
Aliases	MS4A2, APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1, membrane spanning 4-domains A2
External IDs	OMIM: 147138; MGI: 95495; GeneCards: MS4A2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	60,098,467 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	11,601,083 bp
RNA expression pattern
	Top expressed in
	gonad; ; gallbladder; ; testicle; ; rectum; ; monocyte; ; right coronary artery; ; gastric mucosa; ; smooth muscle tissue; ; upper lobe of left lung; ; skin of hip;
	Top expressed in
	renal corpuscle; ; skin of external ear; ; granulocyte; ; dermis; ; otic vesicle; ; embryo; ; blood; ; epithelium of stomach; ; lip; ; bone marrow;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	IgE binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; external side of plasma membrane; Fc-epsilon receptor I complex;
Biological process	Fc-epsilon receptor signaling pathway; cell surface receptor signaling pathway; inflammatory response; immune response; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	2206
	14126
	ENSG00000149534
	ENSMUSG00000024680
	Q01362
	P20490
	NM_000139; NM_001142303; NM_001256916
	NM_001276328; NM_001276329; NM_001276330; NM_013516
	NP_000130; NP_001243845
	NP_001263257; NP_001263258; NP_001263259; NP_038544
	Wikidata
View/Edit Human	View/Edit Mouse

The high affinity immunoglobulin epsilon (IgE) receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene. The protein is a member of the membrane spanning 4A (MS4A) family and constitutes the β subunit of the high-affinity immunoglobulin E (IgE) (FcεRI) receptor complex. It is localized primarily to the surface of the plasma membrane of mast cells and basophils, where it participates in cell surface receptor signaling and signal transduction following allergen binding to receptor-bound IgE antibodies. Activation of the receptor complex induces the release of histamine and other inflammatory mediators that contribute to allergen immune responses. The MS4A2 gene's relationship with IgE makes it clinically relevant in relation to allergy related immune responses.