Prelamin-A/C

LMNA
Identifiers
Aliases	LMNA, CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1, lamin A/C, MADA, A-type lamin
External IDs	OMIM: 150330; MGI: 96794; GeneCards: LMNA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IFR, 1IVT, 1X8Y, 2XV5, 2YPT, 3GEF, 3V4Q, 3V4W, 3V5B
Gene location (Human) Chr. Chromosome 1 (human) Band 1q22 Start 156,082,573 bp End 156,140,081 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 F1|3 38.84 cM Start 88,387,454 bp End 88,417,263 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple gastric mucosa skin of abdomen tendon of biceps brachii gallbladder skin of leg Descending thoracic aorta stromal cell of endometrium Achilles tendon left uterine tube Top expressed in ascending aorta aortic valve external carotid artery internal carotid artery endothelial cell of lymphatic vessel lip condyle skin of back skin of external ear lactiferous gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity protein binding identical protein binding Cellular component nuclear lamina cytosol nuclear speck lamin filament perinuclear region of cytoplasm intermediate filament nucleus extracellular matrix nuclear membrane nucleoplasm nuclear envelope Biological process regulation of cell migration nucleus organization establishment or maintenance of microtubule cytoskeleton polarity negative regulation of release of cytochrome c from mitochondria negative regulation of extrinsic apoptotic signaling pathway muscle organ development regulation of protein localization to nucleus IRE1-mediated unfolded protein response mitotic nuclear membrane disassembly protein localization to nucleus mitotic nuclear membrane reassembly ventricular cardiac muscle cell development cellular response to hypoxia positive regulation of gene expression negative regulation of mesenchymal cell proliferation nuclear envelope organization negative regulation of cell population proliferation regulation of telomere maintenance negative regulation of cardiac muscle hypertrophy in response to stress protein import into nucleus regulation of protein stability positive regulation of histone H3-K9 trimethylation Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 4000 16905 Ensembl ENSG00000160789 ENSMUSG00000028063 UniProt P02545 P48678 RefSeq (mRNA) NM_001257374 NM_001282624 NM_001282625 NM_001282626 NM_005572 NM_170707 NM_170708 NM_001002011 NM_001111102 NM_019390 RefSeq (protein) NP_001244303 NP_001269553 NP_001269554 NP_001269555 NP_005563 NP_733821 NP_733822 NP_001002011 NP_001104572 NP_062263 Location (UCSC) Chr 1: 156.08 – 156.14 Mb Chr 3: 88.39 – 88.42 Mb PubMed search
Wikidata
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Prelamin-A/C, or lamin A/C is a protein that in humans is encoded by the LMNA gene. Lamin A/C belongs to the lamin family of proteins.