KCNK1

KCNK1
Identifiers
Aliases	KCNK1, DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK-1, TWIK1, potassium two pore domain channel subfamily K member 1
External IDs	OMIM: 601745; MGI: 109322; GeneCards: KCNK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3UKM
Gene location (Human)
Chr.	Chromosome 1 (human)
End	233,672,514 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	126,757,424 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; pons; ; endothelial cell; ; cerebellar hemisphere; ; orbitofrontal cortex; ; right hemisphere of cerebellum; ; paraflocculus of cerebellum; ; cartilage tissue; ; corpus epididymis; ; cardiac muscle tissue of right atrium;
	Top expressed in
	seminal vesicula; ; molar; ; choroid plexus of fourth ventricle; ; lobe of cerebellum; ; lobe of prostate; ; mucosa of urinary bladder; ; transitional epithelium of urinary bladder; ; cerebellar vermis; ; Epithelium of choroid plexus; ; submandibular gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	sodium channel activity; potassium ion leak channel activity; voltage-gated potassium channel activity; inward rectifier potassium channel activity; potassium channel activity; protein binding; identical protein binding;
Cellular component	cytoplasm; integral component of membrane; recycling endosome; perikaryon; endosome; cell projection; membrane; voltage-gated potassium channel complex; plasma membrane; integral component of plasma membrane; synapse; inward rectifier potassium channel complex; brush border membrane; cell junction; dendrite; potassium channel complex; apical plasma membrane; cytoplasmic vesicle; intracellular membrane-bounded organelle;
Biological process	sodium ion transmembrane transport; response to nicotine; ion transport; potassium ion transport; cardiac conduction; potassium ion transmembrane transport; regulation of resting membrane potential; stabilization of membrane potential;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	3775
	16525
	ENSG00000135750
	ENSMUSG00000033998
	O00180
	O08581
	NM_002245
	NM_008430
	NP_002236
	NP_032456
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel subfamily K member 1 is a protein that in humans is encoded by the KCNK1 gene.

This gene encodes K_2P1.1, a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, and it may require other non-pore-forming proteins for activity.