ELAV-like protein 1

ELAVL1
Identifiers
Aliases	ELAVL1, ELAV1, HUR, Hua, MelG, ELAV like RNA binding protein 1, HuR
External IDs	OMIM: 603466; MGI: 1100851; GeneCards: ELAVL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3HI9, 4ED5, 4EGL, 4FXV
Gene location (Human)
Chr.	Chromosome 19 (human)
End	8,005,659 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	4,375,413 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; secondary oocyte; ; pericardium; ; mucosa of sigmoid colon; ; ventricular zone; ; corpus epididymis; ; periodontal fiber; ; renal medulla; ; parotid gland; ; caput epididymis;
	Top expressed in
	endocardial cushion; ; abdominal wall; ; mandibular prominence; ; maxillary prominence; ; somite; ; epiblast; ; atrioventricular valve; ; ventricular zone; ; molar; ; cumulus cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; mRNA 3'-UTR binding; protein binding; RNA binding; nucleic acid binding; double-stranded RNA binding; protein kinase binding; mRNA binding; mRNA 3'-UTR AU-rich region binding; miRNA binding;
Cellular component	cytoplasm; cytosol; membrane; nucleoplasm; nucleus; ribonucleoprotein complex; cytoplasmic stress granule; postsynapse; glutamatergic synapse;
Biological process	regulation of mRNA stability; regulation of stem cell population maintenance; positive regulation of translation; multicellular organism development; mRNA stabilization; 3'-UTR-mediated mRNA stabilization; mRNA splicing, via spliceosome; negative regulation of gene silencing by miRNA; protein homooligomerization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	1994
	15568
	ENSG00000066044
	ENSMUSG00000040028
	Q15717
	P70372
	NM_001419
	NM_010485
	NP_001410
	NP_034615
	Wikidata
View/Edit Human	View/Edit Mouse

ELAV-like protein 1 or HuR (human antigen R) is a protein that in humans is encoded by the ELAVL1 gene.

The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements in 3' untranslated regions. One of its best-known functions is to stabilize mRNAs in order to regulate gene expression. Various post-translational modifications of HuR influence its subcellular localization and stability of binding to mRNAs.