Guide RNA

Guide RNA (gRNA) or single guide RNA (sgRNA) is a short sequence of RNA that guides a CRISPR-associated protein to its nucleic acid sequence target by Watson-Crick base pairing. In bacteria and archaea, gRNAs are a part of the CRISPR-Cas system that serves as an adaptive immune defense that protects the organism from viruses. Here the short gRNAs serve as detectors of foreign DNA and direct the Cas-enzymes that degrades the foreign nucleic acid.

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