Gastric inhibitory polypeptide receptor

GIPR
Identifiers
Aliases	GIPR, PGQTL2, gastric inhibitory polypeptide receptor
External IDs	OMIM: 137241; MGI: 1352753; GeneCards: GIPR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HJ0, 2QKH
Gene location (Human)
Chr.	Chromosome 19 (human)
End	45,683,722 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	18,900,052 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; apex of heart; ; right auricle of heart; ; olfactory zone of nasal mucosa; ; body of pancreas; ; granulocyte; ; body of stomach; ; islet of Langerhans; ; minor salivary glands; ; bronchial epithelial cell;
	Top expressed in
	islet of Langerhans; ; embryo; ; morula; ; spermatid; ; blastocyst; ; ventricular zone; ; ganglionic eminence; ; left lung lobe; ; primary visual cortex; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; gastric inhibitory peptide receptor activity; transmembrane signaling receptor activity; protein binding; peptide hormone binding; G protein-coupled peptide receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	response to fatty acid; response to nutrient; regulation of insulin secretion; positive regulation of cytosolic calcium ion concentration; response to glucose; generation of precursor metabolites and energy; activation of adenylate cyclase activity; response to calcium ion; cell surface receptor signaling pathway; gastric inhibitory peptide signaling pathway; response to axon injury; desensitization of G protein-coupled receptor signaling pathway; endocrine pancreas development; signal transduction; positive regulation of insulin secretion; G protein-coupled receptor signaling pathway; positive regulation of cAMP-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	2696
	381853
	ENSG00000010310
	ENSMUSG00000030406
	P48546
	Q0P543
	NM_000164; NM_001308418
	NM_001080815
	NP_000155; NP_001295347
	NP_001074284
	Wikidata
View/Edit Human	View/Edit Mouse

The gastric inhibitory polypeptide receptor (GIP-R), also known as the glucose-dependent insulinotropic polypeptide receptor, is a protein that in humans is encoded by the GIPR gene.

GIP-R is a member of the class B family of G protein–coupled receptors. GIP-R is found on beta-cells in the pancreas, where it serves as the receptor for the gastric inhibitory polypeptide (GIP).