GAD2

GAD2
Identifiers
Aliases	GAD2, GAD65, glutamate decarboxylase 2
External IDs	OMIM: 138275; MGI: 95634; GeneCards: GAD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ES0, 2OKK
Enzyme activity
Gene location (Human)
Chr.	Chromosome 10 (human)
End	26,304,558 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	22,583,886 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; nucleus accumbens; ; beta cell; ; putamen; ; caudate nucleus; ; endothelial cell; ; orbitofrontal cortex; ; external globus pallidus; ; middle frontal gyrus; ; Brodmann area 46;
	Top expressed in
	olfactory tubercle; ; lateral septal nucleus; ; paraventricular nucleus of hypothalamus; ; globus pallidus; ; dorsal tegmental nucleus; ; lateral hypothalamus; ; nucleus accumbens; ; superior frontal gyrus; ; lateral geniculate nucleus; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; catalytic activity; lyase activity; protein heterodimerization activity; pyridoxal phosphate binding; carboxy-lyase activity; glutamate binding; glutamate decarboxylase activity;
Cellular component	cytoplasm; cytosol; Golgi apparatus; membrane; Golgi membrane; plasma membrane; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane; synapse; inhibitory synapse; synaptic vesicle membrane; axon; cell junction; perinuclear region of cytoplasm; anchored component of membrane; presynaptic membrane; cytoplasmic vesicle;
Biological process	carboxylic acid metabolic process; neurotransmitter biosynthetic process; glutamate decarboxylation to succinate; chemical synaptic transmission; neurotransmitter secretion;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	2572
	14417
	ENSG00000136750
	ENSMUSG00000026787
	Q05329
	P48320
	NM_001134366; NM_000818
	NM_008078
	NP_000809; NP_001127838
	NP_032104
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate decarboxylase 2 is an enzyme that in humans is encoded by the GAD2 gene.

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff-person syndrome.