Factor V

This article is about the coagulation protein. For the software company, see Factor 5. For Factor V (NAD), see nicotinamide adenine dinucleotide.

F5
Identifiers
Aliases	F5, FVL, PCCF, RPRGL1, THPH2, coagulation factor V
External IDs	OMIM: 612309; MGI: 88382; GeneCards: F5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3S9C, 1CZS, 1CZV, 3P6Z, 3P70
Gene location (Human) Chr. Chromosome 1 (human) Band 1q24.2 Start 169,511,951 bp End 169,586,588 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 H2.2|1 71.46 cM Start 163,979,407 bp End 164,047,846 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver Epithelium of choroid plexus pancreatic ductal cell placenta optic nerve monocyte olfactory zone of nasal mucosa blood gallbladder granulocyte Top expressed in Epithelium of choroid plexus choroid plexus of fourth ventricle left lobe of liver ciliary body lacrimal gland blood iris granulocyte tibiofemoral joint parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein binding copper ion binding Cellular component platelet alpha granule extracellular vesicle endoplasmic reticulum lumen membrane plasma membrane extracellular region COPII-coated ER to Golgi transport vesicle endoplasmic reticulum-Golgi intermediate compartment membrane platelet alpha granule lumen Golgi apparatus endoplasmic reticulum Golgi membrane extracellular space Biological process hemostasis platelet degranulation blood coagulation blood circulation endoplasmic reticulum to Golgi vesicle-mediated transport COPII vesicle coating response to vitamin K post-translational protein modification Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 2153 14067 Ensembl ENSG00000198734 ENSMUSG00000026579 UniProt P12259 O88783 RefSeq (mRNA) NM_000130 NM_007976 RefSeq (protein) NP_000121 NP_032002 Location (UCSC) Chr 1: 169.51 – 169.59 Mb Chr 1: 163.98 – 164.05 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Coagulation factor V (Factor V), also less commonly known as proaccelerin or labile factor, is a protein involved in coagulation, encoded, in humans, by F5 gene. In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor. Factor V deficiency leads to predisposition for hemorrhage, while some mutations (most notably factor V Leiden) predispose for thrombosis.