Factor H

CFH
Identifiers
Aliases	CFH, AHUS1, AMBP1, ARMD4, ARMS1, CFHL3, FH, FHL1, HF, HF1, HF2, HUS, complement factor H
External IDs	OMIM: 134370; MGI: 88385; GeneCards: CFH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ONT, 1HAQ, 1HCC, 1HFH, 1HFI, 2BZM, 2G7I, 2IC4, 2JGW, 2JGX, 2KMS, 2QFG, 2QFH, 2RLP, 2RLQ, 2UWN, 2V8E, 2W80, 2W81, 2WII, 2XQW, 3GAU, 3GAV, 3GAW, 3KXV, 3KZJ, 3OXU, 3R62, 3RJ3, 3SW0, 4AYD, 4AYE, 4AYI, 4AYM, 4B2R, 4B2S, 4J38, 4K12, 4ZH1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	196,752,476 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	140,111,502 bp
RNA expression pattern
	Top expressed in
	urethra; ; Achilles tendon; ; right coronary artery; ; right lobe of liver; ; saphenous vein; ; synovial joint; ; left coronary artery; ; parietal pleura; ; popliteal artery; ; gallbladder;
	Top expressed in
	body of femur; ; aortic valve; ; aorta; ; vas deferens; ; tunica media of zone of aorta; ; left lobe of liver; ; tunica adventitia of aorta; ; ascending aorta; ; pineal gland; ; uterus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	heparan sulfate proteoglycan binding; heparin binding; protein binding;
Cellular component	extracellular region; blood microparticle; extracellular exosome; extracellular space;
Biological process	complement activation, alternative pathway; regulation of complement activation; immune system process; innate immune response; complement activation; viral process; regulation of complement-dependent cytotoxicity;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	3075
	12628
	ENSG00000000971
	ENSMUSG00000026365
	P08603
	P06909
	NM_001014975; NM_000186
	NM_009888
	NP_000177; NP_001014975
	NP_034018
	Wikidata
View/Edit Human	View/Edit Mouse

Factor H (FH) is a soluble glycoprotein and a member of the regulators of complement activation (RCA) family. It functions as a complement control protein and plays a critical role in regulating the complement system, particularly the alternative pathway. Factor H is a large molecule with a molecular weight of approximately 155 kilodaltons and circulates in human blood plasma at concentrations typically ranging from 200–300 micrograms per milliliter.