FOXO3

FOXO3
Identifiers
Aliases	FOXO3, AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A, forkhead box O3
External IDs	OMIM: 602681; MGI: 1890081; GeneCards: FOXO3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K86, 2LQH, 2LQI, 2UZK
Gene location (Human) Chr. Chromosome 6 (human) Band 6q21 Start 108,559,835 bp End 108,684,774 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10 B2|10 22.79 cM Start 42,057,837 bp End 42,152,751 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte trabecular bone cerebellar vermis nipple middle temporal gyrus visceral pleura buccal mucosa cell tibialis anterior muscle pericardium parietal pleura Top expressed in secondary oocyte zygote fetal liver hematopoietic progenitor cell primary oocyte ciliary body aortic valve ascending aorta cumulus cell blood fossa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function beta-catenin binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding protein kinase binding chromatin DNA binding DNA-binding transcription factor activity sequence-specific DNA binding DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific mitochondrial transcription factor activity transcription coregulator binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription factor binding Cellular component membrane nucleoplasm cytosol cytoplasm nucleus mitochondrion mitochondrial outer membrane mitochondrial matrix protein-containing complex Biological process initiation of primordial ovarian follicle growth ovulation from ovarian follicle regulation of transcription, DNA-templated antral ovarian follicle growth positive regulation of erythrocyte differentiation glucose homeostasis DNA damage response, signal transduction by p53 class mediator tumor necrosis factor-mediated signaling pathway regulation of reactive oxygen species metabolic process transcription by RNA polymerase II regulation of neural precursor cell proliferation transcription, DNA-templated neuronal stem cell population maintenance positive regulation of neuron apoptotic process oocyte maturation extrinsic apoptotic signaling pathway in absence of ligand positive regulation of apoptotic process regulation of translation negative regulation of canonical Wnt signaling pathway apoptotic process negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II cellular response to oxidative stress positive regulation of transcription, DNA-templated positive regulation of reactive oxygen species biosynthetic process brain morphogenesis ageing negative regulation of neuron differentiation cellular response to hypoxia response to water-immersion restraint stress response to nutrient levels cellular response to amyloid-beta cellular response to corticosterone stimulus positive regulation of endothelial cell apoptotic process positive regulation of hydrogen peroxide-mediated programmed cell death response to dexamethasone cellular response to nerve growth factor stimulus cellular response to glucose stimulus anatomical structure morphogenesis cytokine-mediated signaling pathway mitochondrial transcription negative regulation of cell migration insulin receptor signaling pathway positive regulation of autophagy positive regulation of muscle atrophy response to starvation Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 2309 56484 Ensembl ENSG00000118689 ENSMUSG00000048756 UniProt O43524 Q9WVH4 RefSeq (mRNA) NM_001455 NM_201559 NM_019740 NM_001376967 RefSeq (protein) NP_001446 NP_963853 NP_062714 NP_001363896 Location (UCSC) Chr 6: 108.56 – 108.68 Mb Chr 10: 42.06 – 42.15 Mb PubMed search
Wikidata
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Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the FOXO3 gene.