Fibroblast growth factor 8

FGF8
Identifiers
Aliases	FGF8, AIGF, FGF-8, HBGF-8, HH6, KAL6, fibroblast growth factor 8
External IDs	OMIM: 600483; MGI: 99604; GeneCards: FGF8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FDB
Gene location (Human) Chr. Chromosome 10 (human) Band 10q24.32 Start 101,770,109 bp End 101,780,371 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 C3|19 38.75 cM Start 45,725,237 bp End 45,731,354 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad sural nerve Brodmann area 9 monocyte cingulate gyrus anterior cingulate cortex prefrontal cortex right frontal lobe tendon primary visual cortex Top expressed in surface ectoderm Apical ectodermal ridge footplate third ventricle medial nasal prominence pituitary stalk infundibular recess tail of embryo lateral nasal prominence endoderm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function type 1 fibroblast growth factor receptor binding type 2 fibroblast growth factor receptor binding growth factor activity fibroblast growth factor receptor binding chemoattractant activity protein tyrosine kinase activity 1-phosphatidylinositol-3-kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component extracellular region intracellular anatomical structure external side of plasma membrane extracellular space Biological process negative regulation of neuron apoptotic process cell migration involved in mesendoderm migration male genitalia development epithelial to mesenchymal transition involved in endocardial cushion formation outflow tract morphogenesis embryonic heart tube development mesonephros development heart looping forebrain neuron development blood vessel remodeling central nervous system neuron development positive regulation of ERK1 and ERK2 cascade metanephros development cell proliferation in forebrain positive regulation of mitotic nuclear division gonad development pharyngeal system development branching involved in salivary gland morphogenesis apoptotic process dopaminergic neuron differentiation cell fate commitment limb morphogenesis kidney development lung development anatomical structure morphogenesis signal transduction involved in regulation of gene expression regulation of odontogenesis of dentin-containing tooth response to oxidative stress embryo development ending in birth or egg hatching forebrain morphogenesis development of the heart telencephalon development branching involved in ureteric bud morphogenesis midbrain-hindbrain boundary development branching involved in blood vessel morphogenesis thyroid-stimulating hormone-secreting cell differentiation positive chemotaxis mesodermal cell migration cell differentiation dorsal/ventral axon guidance corticotropin hormone secreting cell differentiation organ induction neural plate morphogenesis positive regulation of organ growth negative regulation of apoptotic process BMP signaling pathway outflow tract septum morphogenesis odontogenesis thyroid gland development pallium development gastrulation canonical Wnt signaling pathway subpallium development lung morphogenesis response to organic cyclic compound otic vesicle formation forebrain dorsal/ventral pattern formation heart morphogenesis aorta morphogenesis generation of neurons MAPK cascade neuroepithelial cell differentiation multicellular organism development fibroblast growth factor receptor signaling pathway positive regulation of gene expression negative regulation of cardiac muscle tissue development determination of left/right symmetry inner ear morphogenesis positive regulation of cell population proliferation bone development motor neuron axon guidance positive regulation of cell division embryonic hindlimb morphogenesis phosphatidylinositol phosphate biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process peptidyl-tyrosine phosphorylation positive regulation of cell differentiation regulation of signaling receptor activity positive regulation of protein kinase B signaling positive regulation of G protein-coupled receptor signaling pathway positive regulation of peptidyl-tyrosine phosphorylation Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 2253 14179 Ensembl ENSG00000107831 ENSMUSG00000025219 UniProt P55075 P37237 RefSeq (mRNA) NM_001206389 NM_006119 NM_033163 NM_033164 NM_033165 NM_001166361 NM_001166362 NM_001166363 NM_010205 NM_001379139 NM_001379140 RefSeq (protein) NP_001193318 NP_006110 NP_149353 NP_149354 NP_149355 NP_001159833 NP_001159834 NP_001159835 NP_034335 NP_001366068 NP_001366069 NP_001390029 Location (UCSC) Chr 10: 101.77 – 101.78 Mb Chr 19: 45.73 – 45.73 Mb PubMed search
Wikidata
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Fibroblast growth factor 8 (FGF-8) is a protein that in humans is encoded by the FGF8 gene.