EIF2S1

Not to be confused with EIF2A.

EIF2S1
Identifiers
Aliases	EIF2S1, EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A, eukaryotic translation initiation factor 2 subunit alpha
External IDs	OMIM: 603907; MGI: 95299; GeneCards: EIF2S1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KL9, 1Q8K
Gene location (Human) Chr. Chromosome 14 (human) Band 14q23.3 Start 67,360,328 bp End 67,386,516 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 C3 Start 78,908,593 bp End 78,933,784 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans monocyte gingival epithelium gastrocnemius muscle ganglionic eminence stromal cell of endometrium right ventricle appendix ventricular zone body of pancreas Top expressed in embryo embryo morula morula blastocyst tail of embryo ventricular zone genital tubercle right kidney corneal stroma More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation initiation factor activity ribosome binding protein binding nucleic acid binding RNA binding Cellular component cytoplasm eukaryotic 48S preinitiation complex polysome cytosol ribosome membrane multi-eIF complex eukaryotic translation initiation factor 2B complex glial limiting end-foot translation initiation ternary complex cytoplasmic stress granule extracellular exosome nucleus eukaryotic translation initiation factor 2 complex synapse Biological process cellular response to heat positive regulation of type B pancreatic cell apoptotic process negative regulation of translational initiation in response to stress cellular response to UV cellular response to amino acid starvation ageing response to endoplasmic reticulum stress PERK-mediated unfolded protein response response to manganese-induced endoplasmic reticulum stress transmembrane transport translational initiation protein autophosphorylation regulation of translation regulation of translational initiation in response to stress negative regulation of guanyl-nucleotide exchange factor activity positive regulation of neuron death protein biosynthesis stress granule assembly cellular response to oxidative stress Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 1965 13665 Ensembl ENSG00000134001 ENSMUSG00000021116 UniProt P05198 Q6ZWX6 RefSeq (mRNA) NM_004094 NM_026114 RefSeq (protein) NP_004085 NP_080390 Location (UCSC) Chr 14: 67.36 – 67.39 Mb Chr 12: 78.91 – 78.93 Mb PubMed search
Wikidata
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Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene.