Destrin

DSTN
Identifiers
Aliases	DSTN, ACTDP, ADF, HEL32, bA462D18.2, destrin, actin depolymerizing factor
External IDs	OMIM: 609114; MGI: 1929270; GeneCards: DSTN
Gene location (Human) Chr. Chromosome 20 (human) Band 20p12.1 Start 17,570,075 bp End 17,609,919 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 G1|2 70.89 cM Start 143,757,240 bp End 143,785,244 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein urethra popliteal artery tibial arteries right coronary artery Descending thoracic aorta vena cava ascending aorta superficial temporal artery tail of epididymis Top expressed in Ileal epithelium tunica media of zone of aorta transitional epithelium of urinary bladder corneal stroma left colon umbilical cord lobe of prostate cervix right lung lobe nasal epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function actin binding protein binding actin filament binding Cellular component extracellular exosome cytoplasm actin cytoskeleton cortical actin cytoskeleton intracellular anatomical structure Biological process actin polymerization or depolymerization positive regulation of actin filament depolymerization actin filament severing actin filament depolymerization actin filament fragmentation Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 11034 56431 Ensembl ENSG00000125868 ENSMUSG00000015932 UniProt P60981 Q9R0P5 RefSeq (mRNA) NM_001011546 NM_006870 NM_019771 RefSeq (protein) NP_001011546 NP_006861 NP_062745 Location (UCSC) Chr 20: 17.57 – 17.61 Mb Chr 2: 143.76 – 143.79 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Destrin (actin binding protein)
Nuclear magnetic resonance determined configuration of the tertiary structure of Destrin.
Identifiers
Symbol	DSTN
Alt. symbols	ADF
NCBI gene	11034
HGNC	15750
OMIM	609114
RefSeq	NM_006870
UniProt	P60981
Other data
Locus	Chr. 20 p12.1
Search for Structures Swiss-model Domains InterPro

Destrin or DSTN (also known as actin depolymerizing factor or ADF) is a protein which in humans is encoded by the DSTN gene. Destrin is a component protein in microfilaments.

The product of this gene belongs to the actin-binding proteins ADF (Actin-Depolymerizing Factor)/cofilin family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene.