D arm

The D arm is a conserved structural element of transfer RNA (tRNA) composed of a short D stem and a D-loop that characteristically contains the modified nucleotide dihydrouridine. It plays important roles in stabilizing tRNA tertiary structure and in molecular recognition, particularly by aminoacyl-tRNA synthetases during protein synthesis. Although broadly conserved across Bacteria, Archaea, and Eukaryota, the D arm exhibits structural variation among different tRNA types and organisms, and is absent from certain mitochondrial tRNAs.

Transfer RNA
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