Catechol-O-methyltransferase

COMT
Identifiers
Aliases	COMT, HEL-S-98n, catechol-O-methyltransferase
External IDs	OMIM: 116790; MGI: 88470; GeneCards: COMT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XUE, 3A7E, 3BWM, 3BWY, 4PYI, 4PYJ, 4PYK, 4XUC, 4XUD
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.1.1.6 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 22 (human) Band 22q11.21 Start 19,941,371 bp End 19,969,975 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16 A3|16 11.4 cM Start 18,225,636 bp End 18,245,602 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex stromal cell of endometrium left adrenal gland olfactory bulb left adrenal cortex C1 segment mucosa of pharynx right lobe of liver corpus callosum mucosa of esophagus Top expressed in white adipose tissue right kidney proximal tubule liver human kidney adrenal gland urinary bladder heart striatum of neuraxis duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity O-methyltransferase activity metal ion binding protein binding magnesium ion binding catechol O-methyltransferase activity methyltransferase activity L-dopa O-methyltransferase activity orcinol O-methyltransferase activity Cellular component cytoplasm integral component of membrane cell body cytosol postsynaptic membrane membrane plasma membrane dendritic spine axon dendrite mitochondrion extracellular exosome intracellular membrane-bounded organelle Biological process multicellular organismal reproductive process negative regulation of smooth muscle cell proliferation response to organic cyclic compound regulation of sensory perception of pain estrogen metabolic process cellular response to phosphate starvation catechol-containing compound metabolic process female pregnancy negative regulation of dopamine metabolic process developmental process learning catecholamine metabolic process neurotransmitter catabolic process response to lipopolysaccharide methylation dopamine metabolic process response to pain short-term memory negative regulation of renal sodium excretion dopamine catabolic process positive regulation of homocysteine metabolic process catecholamine catabolic process response to estrogen Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 1312 12846 Ensembl ENSG00000093010 ENSMUSG00000000326 UniProt P21964 O88587 RefSeq (mRNA) NM_000754 NM_001135161 NM_001135162 NM_007310 NM_001362828 NM_001111062 NM_001111063 NM_007744 RefSeq (protein) NP_000745 NP_001128633 NP_001128634 NP_009294 NP_001349757 NP_001104532 NP_001104533 NP_031770 Location (UCSC) Chr 22: 19.94 – 19.97 Mb Chr 16: 18.23 – 18.25 Mb PubMed search
Wikidata
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catechol-O-methyltransferase
Identifiers
EC no.	2.1.1.6
CAS no.	9012-25-3
Databases
BRENDA	enzyme data
ExPASy	NiceZyme view
KEGG	enzyme entry
MetaCyc	metabolic pathway
Rhea	reactions
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Norepinephrine degradation. Catechol-O-methyltransferase is shown in green boxes.

Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), catechol estrogens, and various drugs and substances having a catechol structure. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. Two isoforms of COMT are produced: the soluble short form (S-COMT) and the membrane bound long form (MB-COMT). As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines. COMT was first discovered by the biochemist Julius Axelrod in 1957.