MHC class II transactivator

CIITA
Identifiers
Aliases	CIITA, C2TA, CIITAIV, MHC2TA, NLRA, class II, major histocompatibility complex, transactivator, class II major histocompatibility complex transactivator
External IDs	OMIM: 600005; MGI: 108445; GeneCards: CIITA
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.7.11.1 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 16 (human) Band 16p13.13 Start 10,866,222 bp End 10,943,021 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 A1 Start 10,297,923 bp End 10,346,282 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte appendix spleen lymph node sural nerve gallbladder upper lobe of left lung blood apex of heart Top expressed in mesenteric lymph nodes spleen blood thymus lumbar subsegment of spinal cord subcutaneous adipose tissue duodenum morula right kidney lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity DNA binding nucleotide binding transcription coactivator activity GTP binding kinase activity protein C-terminus binding protein binding acyltransferase activity ATP binding protein-containing complex binding Cellular component PML body nucleoplasm nucleus Biological process positive regulation of MHC class II biosynthetic process regulation of transcription, DNA-templated response to interferon-gamma phosphorylation interferon-gamma-mediated signaling pathway response to antibiotic negative regulation of transcription by RNA polymerase II transcription, DNA-templated positive regulation of transcription, DNA-templated immune response negative regulation of transcription, DNA-templated positive regulation of MHC class I biosynthetic process negative regulation of collagen biosynthetic process positive regulation of transcription by RNA polymerase II inflammatory response Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 4261 12265 Ensembl ENSG00000179583 ENSMUSG00000022504 UniProt P33076 P79621 RefSeq (mRNA) NM_000246 NM_001286402 NM_001286403 NM_001379330 NM_001379331 NM_001379332 NM_001379333 NM_001379334 NM_001243760 NM_001243761 NM_007575 NM_001302618 NM_001302619 RefSeq (protein) NP_000237 NP_001273331 NP_001273332 NP_001366259 NP_001366260 NP_001366261 NP_001366262 NP_001366263 NP_001230689 NP_001230690 NP_001289547 NP_001289548 NP_031601 Location (UCSC) Chr 16: 10.87 – 10.94 Mb Chr 16: 10.3 – 10.35 Mb PubMed search
Wikidata
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MHC class II transactivator is a major histocompatability complex protein encoded in the human by the gene CIITA. Mutations in this gene are responsible for the bare lymphocyte syndrome in which the immune system is severely compromised and cannot effectively fight infection. Chromosomal rearrangement of CIITA is involved in the pathogenesis of Hodgkin lymphoma and primary mediastinal B cell lymphoma.