Antithrombin

SERPINC1
Identifiers
Aliases	SERPINC1, AT3, AT3D, ATIII, THPH7, serpin family C member 1, ATIII-R2, ATIII-T2, ATIII-T1
External IDs	OMIM: 107300; MGI: 88095; GeneCards: SERPINC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4EB1, 1ANT, 1ATH, 1AZX, 1BR8, 1DZG, 1DZH, 1E03, 1E04, 1E05, 1JVQ, 1LK6, 1NQ9, 1OYH, 1R1L, 1SR5, 1T1F, 1TB6, 2ANT, 2B4X, 2B5T, 2BEH, 2GD4, 2HIJ, 2ZNH, 3EVJ, 3KCG
Gene location (Human)
Chr.	Chromosome 1 (human)
End	173,917,378 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	160,833,433 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; gonad; ; stromal cell of endometrium; ; human kidney; ; islet of Langerhans; ; gastrocnemius muscle; ; gastric mucosa; ; metanephros; ; blood; ; renal cortex;
	Top expressed in
	left lobe of liver; ; gallbladder; ; yolk sac; ; human fetus; ; primary oocyte; ; fetal liver hematopoietic progenitor cell; ; zygote; ; secondary oocyte; ; sexually immature organism; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; protease binding; heparin binding; protein binding; serine-type endopeptidase inhibitor activity; identical protein binding;
Cellular component	extracellular region; plasma membrane; blood microparticle; extracellular exosome; extracellular space; endoplasmic reticulum lumen; collagen-containing extracellular matrix;
Biological process	hemostasis; negative regulation of peptidase activity; blood coagulation; regulation of blood coagulation, intrinsic pathway; response to nutrient; negative regulation of endopeptidase activity; lactation; acute inflammatory response to antigenic stimulus; regulation of blood coagulation; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	462
	11905
	ENSG00000117601
	ENSMUSG00000026715
	P01008
	P32261
	NM_000488; NM_001365052
	NM_080844; NM_001379302
	NP_000479; NP_001351981
	NP_543120; NP_001366231
	Wikidata
View/Edit Human	View/Edit Mouse

Antithrombin (AT) is a small glycoprotein that inactivates several enzymes of the coagulation system. It is a 464-amino-acid protein produced by the liver. It contains three disulfide bonds and a total of four possible glycosylation sites. α-Antithrombin is the dominant form of antithrombin found in blood plasma and has an oligosaccharide occupying each of its four glycosylation sites. A single glycosylation site remains consistently un-occupied in the minor form of antithrombin, β-antithrombin. Its activity is increased manyfold by the anticoagulant drug heparin, which enhances the binding of antithrombin to factor IIa (thrombin) and factor Xa.