Amylin

This article is about the polypeptide. For the defunct biotechnology company, see Amylin Pharmaceuticals.

IAPP
Identifiers
Aliases	IAPP, DAP, IAP, islet amyloid polypeptide
External IDs	OMIM: 147940; MGI: 96382; GeneCards: IAPP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KUW, 2G48, 2KB8, 2L86, 3FPO, 3FR1, 3FTH, 3FTK, 3FTL, 3FTR, 3G7V, 3G7W, 3HGZ, 3DG1
Gene location (Human) Chr. Chromosome 12 (human) Band 12p12.1 Start 21,354,959 bp End 21,379,980 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 G2|6 73.81 cM Start 142,244,149 bp End 142,249,687 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans beta cell body of pancreas right lobe of liver left testis right testis duodenum bone marrow female breast lactiferous gland Top expressed in islet of Langerhans pyloric antrum embryo migratory enteric neural crest cell human fetus Paneth cell supraoptic nucleus jejunum Rostral migratory stream crypt of lieberkuhn of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding hormone activity identical protein binding amyloid-beta binding protein binding Cellular component extracellular region soma extracellular space inclusion body Biological process negative regulation of cell differentiation cell-cell signaling sensory perception of pain eating behavior signal transduction negative regulation of bone resorption apoptotic process negative regulation of cell population proliferation protein destabilization protein homooligomerization amyloid fibril formation G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration regulation of signaling receptor activity positive regulation of protein kinase A signaling negative regulation of mitochondrion organization negative regulation of protein homooligomerization positive regulation of apoptotic process positive regulation of MAPK cascade positive regulation of protein kinase B signaling amylin receptor signaling pathway negative regulation of amyloid fibril formation Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 3375 15874 Ensembl ENSG00000121351 ENSMUSG00000041681 UniProt P10997 P12968 RefSeq (mRNA) NM_000415 NM_001329201 NM_010491 RefSeq (protein) NP_000406 NP_001316130 NP_034621 Location (UCSC) Chr 12: 21.35 – 21.38 Mb Chr 6: 142.24 – 142.25 Mb PubMed search
Wikidata
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Amino acid sequence of amylin with disulfide bridge and cleavage sites of insulin degrading enzyme indicated with arrows

Amylin, or islet amyloid polypeptide (IAPP), is a 37-residue peptide hormone. It is co-secreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1 (insulin:amylin). Amylin plays a role in glycemic regulation by slowing gastric emptying and promoting satiety, thereby preventing spikes in blood glucose levels after a meal.

IAPP is processed from an 89-residue coding sequence. Proislet amyloid polypeptide (proIAPP, proamylin, proislet protein) is produced in the pancreatic beta cells (β-cells) as a 67 amino acid, 7404 Dalton pro-peptide and undergoes post-translational modifications including protease cleavage to produce amylin.