ARFGEF2

ARFGEF2
Identifiers
Aliases	ARFGEF2, BIG2, PVNH2, dJ1164I10.1, ADP ribosylation factor guanine nucleotide exchange factor 2
External IDs	OMIM: 605371; MGI: 2139354; GeneCards: ARFGEF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3L8N, 3SWV
Gene location (Human)
Chr.	Chromosome 20 (human)
End	49,036,693 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	166,739,972 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; jejunal mucosa; ; parotid gland; ; Epithelium of choroid plexus; ; corpus epididymis; ; skin of thigh; ; cardia; ; mucosa of sigmoid colon; ; secondary oocyte; ; retinal pigment epithelium;
	Top expressed in
	retinal pigment epithelium; ; lacrimal gland; ; secondary oocyte; ; submandibular gland; ; Epithelium of choroid plexus; ; stroma of bone marrow; ; superior cervical ganglion; ; epithelium of stomach; ; interventricular septum; ; medial vestibular nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity; GABA receptor binding; myosin binding; protein binding; protein kinase A regulatory subunit binding;
Cellular component	cytoplasm; recycling endosome; cytosol; endosome; Golgi apparatus; cell projection; membrane; Golgi membrane; dendritic spine; synapse; microtubule organizing center; cell junction; trans-Golgi network; dendrite; symmetric synapse; asymmetric synapse; perinuclear region of cytoplasm; cytoskeleton; cytoplasmic vesicle; axonemal microtubule;
Biological process	endomembrane system organization; intracellular signal transduction; regulation of ARF protein signal transduction; endosome organization; receptor recycling; positive regulation of tumor necrosis factor production; protein transport; Golgi to plasma membrane transport; exocytosis; transport; regulation of molecular function; vesicle-mediated transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10564
	99371
	ENSG00000124198
	ENSMUSG00000074582
	Q9Y6D5
	A2A5R2
	NM_006420
	NM_001085495
	NP_006411
	NP_001078964
	Wikidata
View/Edit Human	View/Edit Mouse

Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ARFGEF2 gene.