ADAM7

ADAM7
Identifiers
Aliases	ADAM7, ADAM 7, ADAM-7, EAPI, GP-83, GP83, ADAM metallopeptidase domain 7
External IDs	OMIM: 607310; MGI: 107247; GeneCards: ADAM7
Gene location (Human)
Chr.	Chromosome 8 (human)
End	24,526,970 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	68,771,190 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; tail of epididymis; ; testicle; ; caput epididymis; ; seminal vesicula; ; left testis; ; right testis; ; body of pancreas; ; male germ cell; ; gonad;
	Top expressed in
	zygote; ; retinal pigment epithelium; ; secondary oocyte; ; primary oocyte; ; Epithelium of choroid plexus; ; lobe of prostate; ; genital tubercle; ; dorsal striatum; ; white adipose tissue; ; cornea;
	More reference expression data
	n/a
Gene ontology
Molecular function	metallopeptidase activity; metalloendopeptidase activity; endopeptidase activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	proteolysis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8756
	11500
	ENSG00000069206
	ENSMUSG00000022056
	Q9H2U9
	O35227
	NM_003817
	NM_007402
	NP_003808
	NP_031428
	Wikidata
View/Edit Human	View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 7 is a protein that in humans is encoded by the ADAM7 gene. ADAM7 is an 85-kDa enzyme that is a member of the transmembrane ADAM (A Disintegrin and Metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM7 is important for the maturation of sperm cells in mammals. ADAM7 is also denoted as: ADAM_7, ADAM-7, EAPI, GP-83, and GP83.