Actin, cytoplasmic 2

ACTG1
Identifiers
Aliases	ACTG1, ACT, ACTG, BRWS2, DFNA20, DFNA26, HEL-176, actin gamma 1
External IDs	OMIM: 102560; MGI: 87906; GeneCards: ACTG1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5JLH
Gene location (Human)
Chr.	Chromosome 17 (human)
End	81,523,847 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,239,368 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; ventricular zone; ; amniotic fluid; ; embryo; ; ganglionic eminence; ; parietal pleura; ; epithelium of nasopharynx; ; visceral pleura; ; spinal ganglia; ; pericardium;
	Top expressed in
	granulocyte; ; ganglionic eminence; ; neural tube; ; mesencephalon; ; dentate gyrus of hippocampal formation granule cell; ; placenta; ; primary visual cortex; ; epiblast; ; blastocyst; ; stomach;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; ATP binding; ubiquitin protein ligase binding; identical protein binding; structural constituent of cytoskeleton; profilin binding;
Cellular component	focal adhesion; nucleus; dense body; cytoplasm; membrane; cytosol; extracellular exosome; blood microparticle; plasma membrane; cytoskeleton; extracellular matrix; extracellular space; actin cytoskeleton; myofibril; filamentous actin; myelin sheath; actin filament;
Biological process	cell junction assembly; ephrin receptor signaling pathway; platelet aggregation; Fc-gamma receptor signaling pathway involved in phagocytosis; retina homeostasis; vascular endothelial growth factor receptor signaling pathway; membrane organization; sarcomere organization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	71
	11465
	ENSG00000184009
	ENSMUSG00000062825
	P63261
	P63260
	NM_001199954; NM_001614
	NM_009609; NM_001313923
	NP_001186883; NP_001605
	NP_001300852; NP_033739
	Wikidata
View/Edit Human	View/Edit Mouse

Actin, cytoplasmic 2, or gamma-actin is a protein that in humans is encoded by the ACTG1 gene. Gamma-actin is widely expressed in cellular cytoskeletons of many tissues; in adult striated muscle cells, gamma-actin is localized to Z-discs and costamere structures, which are responsible for force transduction and transmission in muscle cells. Mutations in ACTG1 have been associated with nonsyndromic hearing loss and Baraitser-Winter syndrome, as well as susceptibility of adolescent patients to vincristine toxicity.