5-HT_1B receptor

HTR1B
Identifiers
Aliases	HTR1B, 5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12, 5-HT-1B, 5-HT-1D-beta, 5-hydroxytryptamine receptor 1B
External IDs	OMIM: 182131; MGI: 96274; GeneCards: HTR1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4IAQ, 4IAR
Gene location (Human)
Chr.	Chromosome 6 (human)
End	77,463,491 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	81,515,881 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; right coronary artery; ; Descending thoracic aorta; ; left coronary artery; ; ascending aorta; ; stromal cell of endometrium; ; prefrontal cortex; ; nucleus accumbens; ; caudate nucleus;
	Top expressed in
	ventral nuclear group; ; ventral posteromedial nucleus; ; nucleus accumbens; ; ascending aorta; ; lumbar spinal ganglion; ; dorsal nucleus of lateral geniculate body; ; subthalamus; ; ventral posterolateral nucleus; ; paraventricular nucleus of thalamus; ; ventral lateral nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; G protein-coupled serotonin receptor activity; protein binding; neurotransmitter receptor activity; serotonin binding; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;
Cellular component	cytoplasm; integral component of membrane; membrane; integral component of plasma membrane; plasma membrane; calyx of Held; integral component of presynaptic membrane; serotonergic synapse; dendrite;
Biological process	chemical synaptic transmission; G protein-coupled receptor internalization; regulation of dopamine secretion; regulation of behavior; response to mineralocorticoid; vasoconstriction; adenylate cyclase-inhibiting serotonin receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; cellular response to alkaloid; negative regulation of serotonin secretion; cellular response to temperature stimulus; negative regulation of synaptic transmission, GABAergic; protein kinase C-activating G protein-coupled receptor signaling pathway; drinking behavior; bone remodeling; feeding behavior; response to ethanol; negative regulation of synaptic transmission, glutamatergic; signal transduction; response to cocaine; positive regulation of vascular associated smooth muscle cell proliferation; G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; animal behavior; presynaptic modulation of chemical synaptic transmission; regulation of synaptic vesicle exocytosis; regulation of presynaptic cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	3351
	15551
	ENSG00000135312
	ENSMUSG00000049511
	P28222
	P28334
	NM_000863
	NM_010482
	NP_000854
	NP_034612
	Wikidata
View/Edit Human	View/Edit Mouse

5-hydroxytryptamine receptor 1B also known as the 5-HT_1B receptor is a protein that in humans is encoded by the HTR1B gene. The 5-HT_1B receptor is a 5-HT receptor subtype.